Cognitive enrichment
1 paper3 findings
- 1 lab in 1 country
- Humans1
Outcomes
2AD and related dementia neuropathologic indices
no changein humans1
1 study
AD and related dementia neuropathologic indices
no changein humans1
Cognitive enrichment has no effect on AD and related dementia neuropathologic indices in humans.
“In the deceased subset (n = 948), lifetime cognitive enrichment did not show meaningful associations with neuropathologic indices”
Humansdeceased subsetn = 948
Neurology11 Feb 2026
Cognitive decline
downin humans1
1 study
Cognitive decline
downin humans1
Cognitive enrichment decreases cognitive decline in humans (estimate = 0.02, SE = 0.01, p = 0.002).
“Lifetime enrichment was positively associated with cognitive function at baseline (estimate = 0.31, SE = 0.02, p < 0.001) and a slower rate of cognitive decline (estimate = 0.02, SE = 0.01, p = 0.002).”
Humansaverage of 7.6 yearsn = 1,939
Neurology11 Feb 2026
Associations
1Alzheimer's disease dementia
downin humans1HR 0.62
1 study
Alzheimer's disease dementia
downin humans1HR 0.62
Cognitive enrichment lowers the risk of Alzheimer's disease dementia in humans (HR 0.62, 95% CI 0.52-0.73).
“One unit higher in lifetime enrichment was associated with 38% lower hazards of developing AD dementia (hazard ratio 0.62, 95% CI 0.52-0.73, p < 0.001).”
Humansaverage of 7.6 yearsn = 1,939
Neurology11 Feb 2026