Clearance of P16INK4A-POSITIVE cells
Intervention1 paper5 findings
- Animals1
Outcomes
4Lifespan
upin mice1no changein mice1Very low certainty
1 study
Lifespan
upin mice1no changein mice1Very low certainty
Clearance of P16INK4A-POSITIVE cells extend lifespan in mice.
Animalslater (4 months) after sublethal whole-body irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging · Aging cell · 27 Aug 2026
Clearance of P16INK4A-POSITIVE cells have no effect on lifespan in mice.
Animalsearly (1 month) after sublethal whole-body irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging · Aging cell · 27 Aug 2026
Inflammation
downin mice1Very low certainty
1 study
Inflammation
downin mice1Very low certainty
Clearance of P16INK4A-POSITIVE cells decrease inflammation in mice.
Animalslater (4 months) after sublethal whole-body irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging · Aging cell · 27 Aug 2026
Cognitive function
upin mice1Very low certainty
1 study
Cognitive function
upin mice1Very low certainty
Clearance of P16INK4A-POSITIVE cells improve cognitive function in mice.
Animalslater (4 months) after sublethal whole-body irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging · Aging cell · 27 Aug 2026
Frailty
downin mice1Very low certainty
1 study
Frailty
downin mice1Very low certainty
Clearance of P16INK4A-POSITIVE cells decrease frailty in mice.
Animalslater (4 months) after sublethal whole-body irradiation
Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging · Aging cell · 27 Aug 2026