Citrus sinensis
Citrus sinensis has been studied in 3 papers since 2022: 2 trials and 1 observational study in people; 2 in the past year. The newest paper, Jun 30, 2026: “Flavonoid-rich foods, genetic risk, and female breast cancer risk: a prospective cohort study”.
See all 3 papers on citrus sinensis
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“GSH/GSSG ratio increased by 22.4% and 89.0% after 2 and 8 weeks of product intake.”
None of its findings points the other way.
- 1 lab in 1 country
- 4 of 4 findings with company ties
- Human trial2
- Humans1
Studies in people
1 study gave citrus sinensis to people and measured what changed.
| What changed | Design | People | Source |
|---|---|---|---|
up: Increases GSH/GSSG ratio+22.4% at 2 weeks, +89.0% at 8 weeks down: Decreases TNF-alpha-2.5% up: Improves wellbeing | Randomized trial8 weeks | 60 peopleall male (50%) and female (50%)aged between 45 and 60 years old (extremes included)Healthy adults | Nutrients, Oct 11, 2022 |
What did studies of citrus sinensis find?
3Studies of citrus sinensis measured 3 outcomes: GSH/GSSG ratio, wellbeing and TNF-alpha.
GSH/GSSG ratio
upin humans1
1 study
GSH/GSSG ratio
upin humans1
Citrus sinensis increases GSH/GSSG ratio in humans (+22.4% at 2 weeks, +89.0% at 8 weeks).
“Similar consideration can be drawn for the GSH/GSSG ratio that increased by 22.4% and 89.0% after 2 and 8 weeks of use, respectively.”
Human trial8 weeksn = 60
Nutrients
Citrus sinensis increases GSH/GSSG ratio in humans (+89.0% at 8 weeks (+22.4% at 2 weeks)).
“GSH/GSSG ratio increased by 22.4% and 89.0% after 2 and 8 weeks of product intake.”
Human trialstandardized red orange extract8 weeksn = 60
Nutrients
Wellbeing
upin humans1
1 study
Wellbeing
upin humans1
Citrus sinensis improves wellbeing in humans.
“The obtained data suggest a positive effect of the test product in improving the QoL even if more data are needed to confirm or to improve the robustness of the obtained data.”
Human trial8 weeksn = 60
Nutrients
TNF-alpha
downin humans1−2.5%
1 study
TNF-alpha
downin humans1−2.5%
Citrus sinensis decreases TNF-alpha in humans (-2.5%).
“In the active treatment arm, the basal (7.19 ± 0.07 pg/mL) concentration of TNF-a was statistically significant decreased by 2.5% (7.00 ± 0.09 pg/mL, p = 0.0335) after 8 weeks of use, respectively ( b), while do not was statistically significant in the placebo treatment arm.”
Human trial8 weeksn = 60
Nutrients