Circadian rest-activity rhythm disruption

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Beijing Nova Program and 2 more

Humans1

Associations

Cardiovascular mortality

upin humans1

1 study

Circadian rest-activity rhythm disruption raises the risk of cardiovascular mortality in humans.
“Low amplitude and mesor were significantly linked to increased risks of all-cause and cardiovascular mortality.”
Humansn = 4,893
Sex differences in the association between circadian rest-activity rhythms and cardiovascular disease among middle-aged and elderly adults
Chronobiology international23 Mar 2026

Mortality

upin humans1

1 study

Circadian rest-activity rhythm disruption raises the risk of mortality in humans.
“Low amplitude and mesor were significantly linked to increased risks of all-cause and cardiovascular mortality.”
Humansn = 4,893
Sex differences in the association between circadian rest-activity rhythms and cardiovascular disease among middle-aged and elderly adults
Chronobiology international23 Mar 2026

Cardiovascular disease

upin humans1

1 study

Circadian rest-activity rhythm disruption raises the risk of cardiovascular disease in humans (64% higher odds (95% CI, 1.11-2.43)).
“those in the lowest quintile of CRAR amplitude had 64% higher odds of CVD than those in higher quintiles (95% CI, 1.11-2.43).”
Humansn = 4,893
Sex differences in the association between circadian rest-activity rhythms and cardiovascular disease among middle-aged and elderly adults
Chronobiology international23 Mar 2026

Latest

1 in 12 months

Chronobiology International23 Mar

Sex differences in the association between circadian rest-activity rhythms and cardiovascular disease among middle-aged and elderly adults

Cohort study of 4,893 peopleCardiovascular disease

Paper

Circadian rest-activity rhythm disruption

Associations

Latest

Sex differences in the association between circadian rest-activity rhythms and cardiovascular disease among middle-aged and elderly adults

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