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Cinnamaldehyde

Intervention

2 papers study it3 more mention it6 findings

PubChemChEBIMeSH

Across all fields, 2 papers: none in people yet, 2 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: Common Fund and 4 more
  • Model organisms2

Outcomes

5

Lifespan

upin flies1upin worms1

2 studies

  1. Cinnamaldehyde extends lifespan in worms.

    “feeding worms cinnamaldehyde (CA), the active ingredient in cinnamon oil, prolongs longevity.”

    Model organisms

    Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling

    Aging cell

  2. Cinnamaldehyde extends lifespan in flies.

    “We found that cinnamaldehyde significantly improved the lifespan of both AD and non-AD flies.”

    Model organismsAD and non-AD flies

    Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease

    BioMed research international

Nutrient sensing

upin worms1

1 study

  1. Cinnamaldehyde induces nutrient sensing in worms.

    “CA promotes longevity by inducing a dietary restriction-like state without affecting food intake”

    Model organismswithout affecting food intake

    Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling

    Aging cell

More on Nutrient sensing

β-Amyloid toxicity

downin worms1

1 study

  1. Cinnamaldehyde decreases β-Amyloid toxicity in worms.

    “reduces β-Amyloid toxicity in a C. elegans model of Alzheimer's disease.”

    Model organismsin a C. elegans model of Alzheimer's disease

    Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling

    Aging cell

Healthspan

no changein flies1

1 study

  1. Cinnamaldehyde has no effect on healthspan in flies (No positive impact reported).

    “Cinnamaldehyde had no positive impact on the healthspan of AD flies overexpressing the Aβ42 protein.”

    Model organismsAD flies overexpressing Aβ42

    Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease

    BioMed research international

Climbing ability

upin flies1

1 study

  1. Cinnamaldehyde improves climbing ability in flies.

    “Cinnamaldehyde also improved the healthspan of AD flies overexpressing the Tau protein by improving climbing ability”

    Model organismsAD flies overexpressing Tau

    Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease

    BioMed research international

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