Chronic sleep restriction

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Institutes of Health and 4 more

Animals2

Outcomes

Cytosolic Ca2+

upin rats1

1 study

Chronic sleep restriction increases cytosolic Ca2+ in rats.
“glutamate and carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) induced a greater elevation in cytosolic Ca2+ ([Ca2+](c)) in hippocampal slices from aged rats subjected to CSR compared to age-matched controls”
Animalsin hippocampal slices from aged ratshippocampus
Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals
Progress in neuro-psychopharmacology & biological psychiatry7 Feb 2012

Associations

Complement and coagulation pathway enrichment

upin mice1

1 study

Chronic sleep restriction is associated with complement and coagulation pathway enrichment in mice.
“the complement and coagulation cascade pathways were enriched by alterations of complement component 3 (C3), fibrinogen alpha and beta chain (FGA and FGB).”
Animalspathway analysis of proteins common to sleep restriction and agingcerebral cortex
Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging
Npj biological timing and sleep27 Jan 2026

Cortical protein abundance

mixedin mice1

1 study

Chronic sleep restriction is associated with cortical protein abundance in mice (145 sleep-related proteins altered; 71 shared with age-related alterations).
“We report the alteration of 145 proteins related to sleep and 1275 related to age, with 71 proteins common between them.”
Animalswild-type mice subjected to chronic sleep restrictioncerebral cortex
Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging
Npj biological timing and sleep27 Jan 2026