Cortical protein abundance

1. Chronic sleep restriction is associated with cortical protein abundance in mice (145 sleep-related proteins altered; 71 shared with age-related alterations).

   “We report the alteration of 145 proteins related to sleep and 1275 related to age, with 71 proteins common between them.”

   Animalswild-type mice subjected to chronic sleep restrictioncerebral cortex

   Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging

   Npj biological timing and sleep·27 Jan 2026

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