Chip-overexpressing adipose-derived stem cells
Chip-overexpressing adipose-derived stem cells has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Dec 11, 2023: “Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats”.
1 paper studies it2 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funder: Ministry of Science and Technology, Taiwan
- Animals1
What did studies of Chip-overexpressing adipose-derived stem cells find?
2Studies of Chip-overexpressing adipose-derived stem cells measured 2 outcomes; the most studied are heart size (1 study) and cardiac function (1).
Heart size
downin rats1
1 study
Heart size
downin rats1
Chip-overexpressing adipose-derived stem cells decrease heart size in rats.
“as well as a decrease in their heart size and heart rate, respectively.”
Animalsaging-SHRheart
Aging
Cardiac function
upin rats1
1 study
Cardiac function
upin rats1
Chip-overexpressing adipose-derived stem cells improve cardiac function in rats (≈15% vs. control SHR).
“transplantation of lentiviral CHIP overexpression of rADSCs (rADSCsCHIP-WT) into nine months aging-SHR led to an increase in their cardiac function - increased ejection fraction and fractional shortening (≈15% vs. control SHR)”
Animalsaging-SHRheart
Aging