Cephaloridine

1. Cephaloridine decreases age-related metabolic changes in mice.

   “oral administration of low-dose cephaloridine induced transcription of the capsular polysaccharide synthesis (cps) operon responsible for CA biosynthesis in commensal E. coli at 37 °C, and attenuated age-related metabolic changes.”

   Animalsgutlow-dose

   Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts

   PLoS biology·11 Nov 2025

1. Cephaloridine induces colanic acid in E. coli cells.

   “wild-type Escherichia coli strains overproduce colanic acids (CAs) when exposed to a low dose of cephaloridine”

   Cellslow dose

   Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts

   PLoS biology·11 Nov 2025

More on Colanic acid

1. Cephaloridine extends lifespan in worms.

   “exposed to a low dose of cephaloridine, leading to an increased life span in the host organism Caenorhabditis elegans.”

   Model organismslow dose

   Chemical modulation of gut bacterial metabolism induces colanic acid and extends the lifespan of nematode and mammalian hosts

   PLoS biology·11 Nov 2025