Cd4+ t cell transplantation
Cd4+ t cell transplantation has been studied in 1 paper since 2021: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Feb 19, 2021: “Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging”.
1 paper studies it3 findingsUpdated
See all 1 papers on cd4+ t cell transplantation
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 4 more
- Animals1
What did studies of cd4+ t cell transplantation find?
3Studies of cd4+ t cell transplantation measured 3 outcomes; the most studied are inflammation (1 study), myocardial immune cell infiltration (1) and CD4+ T cell terminal differentiation (1).
Inflammation
upin mice1
1 study
Inflammation
upin mice1
Cd4+ t cell transplantation increases inflammation in young NSG-DR1 mice.
“expanding T-cells promote myocardial inflammaging, marked by a distinct age-related transcriptomic signature”
Animalsin young NSG-DR1 micemyocardium
Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging
Frontiers in immunology
Myocardial immune cell infiltration
upin mice1
1 study
Myocardial immune cell infiltration
upin mice1
Cd4+ t cell transplantation increases myocardial immune cell infiltration in young NSG-DR1 mice.
“young mice harboring an expanded CD4+ T cell compartment showed increased numbers of infiltrating monocytes, macrophages and dendritic cells in the heart”
Animalsin young NSG-DR1 miceheart
Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging
Frontiers in immunology
CD4+ T cell terminal differentiation
upin mice1
1 study
CD4+ T cell terminal differentiation
upin mice1
Cd4+ t cell transplantation induces CD4+ T cell terminal differentiation in young lymphocyte-deficient NSG-DR1 mice.
“CD4+ T cells underwent homeostatic expansion, upregulated expression of PD-1 receptor and strongly shifted towards effector/memory (CCR7− CD45RO+) and terminally-differentiated phenotypes (CCR7−CD45RO−)”
Animalsin young lymphocyte-deficient NSG-DR1 mice
Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging
Frontiers in immunology