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CD38-TARGETING peptide vaccine

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Beijing Municipal Natural Science Foundation and 3 more
  • Animals1

Outcomes

5

NAD/NADH ratio

upin mice1

1 study

  1. CD38-TARGETING peptide vaccine increases NAD/NADH ratio in mice.

    “Vaccination also increases the NAD+/NADH ratio in the liver tissues”

    Animalsliver

    CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice

    Aging cell25 Jun 2025

More on NAD/NADH ratio

Cellular senescence

downin mice1

1 study

  1. CD38-TARGETING peptide vaccine decreases cellular senescence in mice.

    “decreases the number of senescent cells and mRNA levels of senescence-related genes in liver tissues”

    Animalsliver

    CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice

    Aging cell25 Jun 2025

More on Cellular senescence

Cognitive function

upin mice1

1 study

  1. CD38-TARGETING peptide vaccine improves cognitive function in mice.

    “ameliorates age-related physical and cognitive function decline”

    Animals

    CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice

    Aging cell25 Jun 2025

Physical function

upin mice1

1 study

  1. CD38-TARGETING peptide vaccine improves physical function in mice.

    “ameliorates age-related physical and cognitive function decline”

    Animals

    CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice

    Aging cell25 Jun 2025

CD38+ myeloid cells

downin mice1

1 study

  1. CD38-TARGETING peptide vaccine decreases CD38+ myeloid cells in mice.

    “selectively depletes CD38+ myeloid cells in the spleen”

    Animalsspleen

    CD38-Targeting Peptide Vaccine Ameliorates Aging-Associated Phenotypes in Mice

    Aging cell25 Jun 2025

More on CD38+ myeloid cells

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