Cardiac glycosides

1. Cardiac glycosides decrease senescent-cell abundance in mice.

   “cardiac glycosides synergize with anti-cancer drugs to kill tumor cells and eliminate senescent cells that accumulate after irradiation or in old mice.”

   Animals

   Cardiac glycosides are broad-spectrum senolytics

   Nature metabolism·21 Oct 2019

More on Senescent-cell abundance

1. Cardiac glycosides increase tumor cell killing in mouse cells.

   “cardiac glycosides synergize with anti-cancer drugs to kill tumor cells”

   Cellsin combination with anti-cancer drugs

   Cardiac glycosides are broad-spectrum senolytics

   Nature metabolism·21 Oct 2019

1. Cardiac glycosides decrease pulmonary fibrosis in mice.

   “The senolytic effect of CGs is also effective in the elimination of senescence-induced lung fibrosis.”

   Animalssenescence-induced

   Identification and characterization of Cardiac Glycosides as senolytic compounds

   Nature communications·21 Oct 2019

More on Pulmonary fibrosis

1. Cardiac glycosides decrease tumor in mice.

   “in vivo eradication of tumors xenografted in mice after treatment with the combination of a senogenic and a senolytic drug”

   Animalscombination with a senogenic drug

   Identification and characterization of Cardiac Glycosides as senolytic compounds

   Nature communications·21 Oct 2019

More on Tumor

1. Cardiac glycosides decrease senescent cells in mouse cells.

   “CGs, by targeting the Na+/K+ATPase pump, cause a disbalanced electrochemical gradient within the cell causing depolarization and acidification.”

   Cellssenescent cells

   Identification and characterization of Cardiac Glycosides as senolytic compounds

   Nature communications·21 Oct 2019