Carbonyl cyanide m-chlorophenyl hydrazone

1. Carbonyl cyanide m-chlorophenyl hydrazone has no effect on cell proliferation arrest in C. carpio cells.

   “this did not result in permanent cell proliferation arrest or the upregulation of endogenous Ras expression.”

   Cellswith CCCP-induced mitochondrial dysfunction in EPC fish cells

   Mitochondrial dysfunction matures Ras-induced early senescence to full senescence with a proinflammatory senescence-associated secretory phenotype in the fish cell line, EPC

   Biochemical and biophysical research communications·Oct 12, 2024

1. Carbonyl cyanide m-chlorophenyl hydrazone induces senescence-associated secretory phenotype (SASP) in C. carpio cells.

   “EPC cells with mitochondrial dysfunction exhibited a proinflammatory SASP”

   Cellsin EPC fish cells

   Mitochondrial dysfunction matures Ras-induced early senescence to full senescence with a proinflammatory senescence-associated secretory phenotype in the fish cell line, EPC

   Biochemical and biophysical research communications·Oct 12, 2024

More on Senescence-associated secretory phenotype (SASP)

1. Carbonyl cyanide m-chlorophenyl hydrazone increases cell proliferation in human cells.

   “effectively inhibiting cell senescence and apoptosis while promoting cell proliferation.”

   Cellsin uric acid- and hydroxychloroquine-treated HUVECshuman umbilical vein endothelial cells

   Hyperuricemia Facilitates Uric Acid-Mediated Vascular Endothelial Cell Damage by Inhibiting Mitophagy

   Cell biochemistry and biophysics·Sep 28, 2024

1. Carbonyl cyanide m-chlorophenyl hydrazone inhibits cellular senescence in human cells.

   “effectively inhibiting cell senescence and apoptosis while promoting cell proliferation.”

   Cellsin uric acid- and hydroxychloroquine-treated HUVECshuman umbilical vein endothelial cells

   Hyperuricemia Facilitates Uric Acid-Mediated Vascular Endothelial Cell Damage by Inhibiting Mitophagy

   Cell biochemistry and biophysics·Sep 28, 2024

More on Cellular senescence