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Calcitriol + conjugated equine estrogens + medroxyprogesterone acetate

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Institute on Aging
  • Human trial1

Outcomes

1

Rate of falls

downin humans1

1 study

  1. Calcitriol + conjugated equine estrogens + medroxyprogesterone acetate decreases rate of falls in humans (-61% (95% CI -76% to -37%)).

    “calcitriol + ET/HT by 61% (95% CI -76% to -37%; P = 0.001)”

    Human trialin the low CrCl group (<60 ml/min)3-yrfemales

    An age-related decrease in creatinine clearance is associated with an increase in number of falls in untreated women but not in women receiving calcitriol treatment

    The Journal of clinical endocrinology and metabolism10 Oct 2006

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