Caffeine + taurine

1. Caffeine + taurine improves reaction time in humans (g = 0.75, 95% CrI [0.29, 1.18]).

   “CAF+TAU was associated with a credible positive effect on anaerobic capacity (g = 0.46, 95% CrI [0.19, 0.71]) and reaction time (g = 0.75, 95% CrI [0.29, 1.18]) compared to CAF or TAU alone.”

   Review

   Caffeine and taurine: a systematic review and network meta-analysis of their individual and combined effects on physical capacity, cognitive function, and physiological markers

   Journal of the International Society of Sports Nutrition·Oct 1, 2025

2. Caffeine + taurine improves reaction time in humans (326 versus 299 ms).

   “or caffeine plus taurine (326 versus 299 ms; P = 0·110) was administered.”

   Human trialfollowing sleep deprivation150 mg caffeine combined with 2 g taurinen = 18

   Effect of caffeine and taurine on simulated laparoscopy performed following sleep deprivation

   The British journal of surgery·Jul 14, 2011

1. Caffeine + taurine has no effect on time to exhaustion in humans (p = 0.608).

   “There were no differences in TTE between conditions (p = 0.608)”

   Human trialcycling in the heat (35°C; 40% relative humidity) at the gas exchange thresholdoral5 mg/kg caffeine + 50 mg/kg taurine1 h after ingestionn = 10

   Acute Effects of Caffeine and Taurine Co-Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat

   European journal of sport science·Oct 1, 2025

2. Caffeine + taurine improves time to exhaustion in humans (613.69 + 37.74 s, p = 0.041, d = 0.902).

   “taurine + caffeine (TC: 613.69 + 37.74 s, p = 0.041, d = 0.902) groups significantly improved time to exhaustion compared to the placebo group.”

   Human trialhypoxic environment50 mg/kg + 5 mg/kgmalesn = 16

   Effects of taurine combined with caffeine on repetitive sprint exercise performance and cognition in a hypoxic environment

   Scientific reports·Feb 13, 2025

1. Caffeine + taurine improves endurance performance in humans.

   “All experimental groups improved TTE compared with the placebo group.”

   Human trialin high temperature and humidity environments (35°C, 65% relative humidity)n = 12

   Effects of Caffeine-Taurine Co-Ingestion on Endurance Cycling Performance in High Temperature and Humidity Environments

   Sports health·Feb 26, 2024

2. Caffeine + taurine improves endurance performance in mice.

   “The use of caffeine and taurine over a 2 week period enhanced endurance performance.”

   Animals2 week

   Caffeine and taurine enhance endurance performance

   International journal of sports medicine·May 19, 2009

1. Caffeine + taurine improves anaerobic capacity in humans (g = 0.46, 95% CrI [0.19, 0.71]).

   “CAF+TAU was associated with a credible positive effect on anaerobic capacity (g = 0.46, 95% CrI [0.19, 0.71]) and reaction time (g = 0.75, 95% CrI [0.29, 1.18]) compared to CAF or TAU alone.”

   Review

   Caffeine and taurine: a systematic review and network meta-analysis of their individual and combined effects on physical capacity, cognitive function, and physiological markers

   Journal of the International Society of Sports Nutrition·Oct 1, 2025

1. Caffeine + taurine has no effect on core temperature in humans (p = 0.699).

   “There were no differences between conditions for skin (p = 0.539) and core temperature (p = 0.699)”

   Human trialcycling in the heat (35°C; 40% relative humidity) at the gas exchange thresholdoral5 mg/kg caffeine + 50 mg/kg taurine1 h after ingestionn = 10

   Acute Effects of Caffeine and Taurine Co-Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat

   European journal of sport science·Oct 1, 2025

More on Core temperature

1. Caffeine + taurine increases oxygen consumption rate in humans (p = 0.017).

   “the rate of oxygen consumption (p = 0.017), minute ventilation (p = 0.029) and heat production (p = 0.019) were higher following the supplement”

   Human trialcycling in the heat (35°C; 40% relative humidity) at the gas exchange thresholdoral5 mg/kg caffeine + 50 mg/kg taurine1 h after ingestionn = 10

   Acute Effects of Caffeine and Taurine Co-Ingestion on Time to Exhaustion and Thermoregulatory Responses to Cycling in the Heat

   European journal of sport science·Oct 1, 2025

More on Oxygen consumption rate

1. Caffeine + taurine decreases neutral reaction time in humans.

   “In terms of cognitive performance, co-ingestion of CAF*TAU significantly improved the neutral reaction time (ms) compared to the TAU, CAF and PLA groups.”

   Human trialafter Wingate testco-ingestion6 mg/kg caffeine + 3 g taurinemalesn = 20

   Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study

   Nutrients·Oct 20, 2022

1. Caffeine + taurine improves balance and agility in humans (p < 0.05).

   “According to the balance and agility tests performed after the Wingate test, co-ingestion of CAF*TAU revealed a significant difference (p < 0.05) compared to the PLA group.”

   Human trialafter Wingate testco-ingestion6 mg/kg caffeine + 3 g taurinemalesn = 20

   Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study

   Nutrients·Oct 20, 2022

1. Caffeine + taurine improves wingate anaerobic test performance in humans (p < 0.05).

   “co-ingestion of CAF*TAU, improved peak (W/kg), average (W), minimum (W) power, time to reach (s), and RPE performances compared to the PLA group significantly (p < 0.05).”

   Human trialWingate testco-ingestion6 mg/kg caffeine + 3 g taurinemalesn = 20

   Does Single or Combined Caffeine and Taurine Supplementation Improve Athletic and Cognitive Performance without Affecting Fatigue Level in Elite Boxers? A Double-Blind, Placebo-Controlled Study

   Nutrients·Oct 20, 2022

1. Caffeine + taurine increases blood lactate in humans (likely small to possibly small).

   “increases in B[la] after sprints 5 (likely small) and 10 (possibly small)”

   Human trialafter sprints 5 and 10gelatine capsulecaffeine (80 mg) and taurine (1 g)one hour after ingestingmalesn = 11

   Energy Drink Doses of Caffeine and Taurine Have a Null or Negative Effect on Sprint Performance

   Journal of strength and conditioning research·Dec 1, 2020

More on Blood lactate