Cad polygenic risk score prognostic enrichment

Cad polygenic risk score prognostic enrichment decreases required sample size in silico (~25% (8,109 vs. 10,833)).

“reduced the required sample size by ~25% (8,109 vs. 10,833) to achieve 90% with 3 years of follow-up”

In silicoprimary prevention cohort without previous ASCVD3 years of follow-upn = 16,569

Polygenic Risk Score–Based Enrichment of Primary Prevention Cohorts for Atherosclerotic Cardiovascular Disease Trials

AHA Scientific Sessions 2025 abstract·3 Nov 2025

Cad polygenic risk score prognostic enrichment increases statistical power in silico (0.87 vs. 0.80).

“recruiting only the high-risk PRS group reduced time-to-90%-power by approximately 2.4 years (Figure), increased power over 3 years (0.87 vs. 0.80)”

In silicoprimary prevention cohort without previous ASCVD3 yearsn = 16,569

Polygenic Risk Score–Based Enrichment of Primary Prevention Cohorts for Atherosclerotic Cardiovascular Disease Trials

AHA Scientific Sessions 2025 abstract·3 Nov 2025