Bumetanide

2 papers2 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funders: National Center for Advancing Translational Sciences and 5 more

Humans2

Outcomes

1

Cognitive deficits

downin mice1

1 study

Bumetanide decreases cognitive deficits in mice.
“Bumetanide treatment of apoE4 mice without or with Aβ accumulation rescued electrophysiological, pathological, or cognitive deficits.”
Animalsin apoE4 mice without or with Aβ accumulation
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
Nature agingOct 11, 2021

Associations

1

Alzheimer's disease

downin humans1

1 study

Bumetanide lowers the risk of Alzheimer's disease in humans.
“bumetanide exposure was associated with a significantly lower AD prevalence in individuals over the age of 65 in two electronic health record databases”
Humans
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease
Nature agingOct 11, 2021

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