Box-a
Box-a has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Jul 27, 2016: “The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming”.
1 paper studies it3 findingsUpdated
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of Dental and Craniofacial Research and 2 more
- Animals1
What did studies of Box-a find?
3Studies of Box-a measured 3 outcomes; the most studied are microglial proinflammatory response (1 study), cognitive and affective behavioral changes (1) and hippocampal cytokine response (1).
Microglial proinflammatory response
downin rats1
1 study
Microglial proinflammatory response
downin rats1
Box-a inhibits microglial proinflammatory response in rats (lipopolysaccharide challenge ex vivo following pretreatment of aged rats).
“ICM pretreatment with Box-A also inhibited aging-induced potentiation of the microglial proinflammatory response to lipopolysaccharide ex vivo”
Animalslipopolysaccharide challenge ex vivo following pretreatment of aged ratsmicroglia
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cognitive and affective behavioral changes
downin rats1
1 study
Cognitive and affective behavioral changes
downin rats1
Box-a prevents cognitive and affective behavioral changes in rats (aged rats with peripheral Escherichia coli infection).
“Box-A 24 h before E. coli infection prevented the extended hippocampal cytokine response and associated cognitive and affective behavioral changes.”
Animalsaged rats with peripheral Escherichia coli infection24 h before infection
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hippocampal cytokine response
downin rats1
1 study
Hippocampal cytokine response
downin rats1
Box-a prevents hippocampal cytokine response in rats (aged rats with peripheral Escherichia coli infection).
“ICM pretreatment of aged rats with Box-A 24 h before E. coli infection prevented the extended hippocampal cytokine response”
Animalsaged rats with peripheral Escherichia coli infectionhippocampus24 h before infection
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
The Journal of neuroscience : the official journal of the Society for Neuroscience