Botulinum neurotoxin
1 paper4 findings
- 1 lab in 1 country
- Funders: International Mental Health Research Organization and 4 more
- Animals1
Outcomes
4Nitric oxide
downin mice1
1 study
Nitric oxide
downin mice1
Botulinum neurotoxin decreases nitric oxide in mice.
“reduced NO levels in the hippocampus of BoNT-treated animals.”
Animalshippocampusfour weeks
World journal of experimental medicine20 Dec 2025
PTGS2
downin mice1
1 study
PTGS2
downin mice1
Botulinum neurotoxin decreases PTGS2 in mice.
“decreased mRNA expression of COX-2 and reduced NO levels in the hippocampus of BoNT-treated animals.”
Animalshippocampusfour weeks
World journal of experimental medicine20 Dec 2025
Activated microglia
downin mice1
1 study
Activated microglia
downin mice1
Botulinum neurotoxin decreases activated microglia in mice.
“This enhancement in neurogenesis was accompanied by a marked reduction in the activated form of microglial cells”
Animalshippocampusfour weeks
World journal of experimental medicine20 Dec 2025
neurogenesis
upin mice1
1 study
neurogenesis
upin mice1
Botulinum neurotoxin increases neurogenesis in mice.
“The results revealed a significant increase in the number of DCX-positive immature neurons and BrdU-NeuN positive differentiated neurons in the hippocampus of the BoNT-treated group compared to the control.”
Animalshippocampusfour weeks
World journal of experimental medicine20 Dec 2025
Latest
1 in 12 monthsWorld Journal of Experimental Medicine
Proneurogenic and microglial modulatory properties of botulinum neurotoxin in the hippocampus of aging experimental mice
Experiments in miceInterventions