Blast exposure

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: U.S. Department of Veterans Affairs
1 of 2 findings with company ties

Humans2

Outcomes

DunedinPACE

upin humans1

1 study

Blast exposure increases DunedinPACE in humans (B = 0.12, P = .042).
“Greater blast exposure severity was significantly associated with faster DunedinPACE scores (B = 0.12; P = .042), indicating accelerated biological aging.”
Humansadjusting for demographic and technical covariates, PTSD, and TBIwhole bloodn = 114
Accelerated Epigenetic Aging in Veterans Exposed to Blast
The Journal of head trauma rehabilitation18 Mar 2026

Associations

Mild cognitive impairment

upin humans1

1 study

Blast exposure is associated with mild cognitive impairment in humans.
“occupations with high risk for low‐level blast, were associated with higher age‐ and sex‐adjusted rates of MCI and ADRD diagnoses.”
Humansn = 146,670
Incidence and correlates of mild cognitive impairment, Alzheimer's disease, and related dementias among post‐9/11 Veterans: Findings from the Millennium Cohort Study
AAIC 2025 abstract23 Dec 2025