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Bisphenol tmc

Intervention

1 paper5 findings

PubChem 4134035

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Korea Institute of Toxicology and 3 more
  • Model organisms1

Outcomes

5

Mitochondrial population

downin worms1

1 study

  1. Bisphenol tmc decreases mitochondrial population in worms.

    “Additionally, BPTMC increased reactive oxygen species levels but decreased mitochondrial population.”

    Model organisms

    Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

    Ecotoxicology and environmental safety9 Aug 2025

More on Mitochondrial population

Reactive oxygen species

upin worms1

1 study

  1. Bisphenol tmc increases reactive oxygen species in worms.

    “Additionally, BPTMC increased reactive oxygen species levels but decreased mitochondrial population.”

    Model organisms

    Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

    Ecotoxicology and environmental safety9 Aug 2025

More on Reactive oxygen species

Mitochondrial unfolded protein response

upin worms1

1 study

  1. Bisphenol tmc induces mitochondrial unfolded protein response in worms.

    “exposure to BPTMC resulted in mitochondrial unfolded protein response (mitoUPR)”

    Model organisms

    Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

    Ecotoxicology and environmental safety9 Aug 2025

More on Mitochondrial unfolded protein response

Reproduction

downin worms1

1 study

  1. Bisphenol tmc decreases reproduction in worms.

    “C. elegans exposed to 1 mM BPTMC exhibited developmental delays, reduced reproduction, and diminished longevity.”

    Model organisms1 mM

    Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

    Ecotoxicology and environmental safety9 Aug 2025

Lifespan

downin worms1

1 study

  1. Bisphenol tmc shortens lifespan in worms.

    “C. elegans exposed to 1 mM BPTMC exhibited developmental delays, reduced reproduction, and diminished longevity.”

    Model organisms1 mM

    Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

    Ecotoxicology and environmental safety9 Aug 2025

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