Benfluorex
Benfluorex has been studied in 1 paper since 1995: 1 trial in people. The newest paper, Feb 1, 1995: “Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men”.
See all 1 papers on benfluorex
At a glance
The findings reach people, from one lab or study. 1 lab.
“Benfluorex treatment lowered diastolic and systolic blood pressures and improved glucose tolerance in both age groups.”
None of its findings points the other way.
- 1 lab
- Funder: National Institute on Aging
- Human trial1
Studies in people
1 study gave benfluorex to people and measured what changed.
| What changed | Design | People | Source |
|---|---|---|---|
down: Decreases blood pressure up: Improves glucose tolerance down: Decreases insulin response | Randomized trial6 weeks | 27 peopleMen30-80 yr oldMidlife adults; Older adults; hypertension, insulin resistance | The Journal of clinical endocrinology and metabolism, Feb 1, 1995 |
What did studies of benfluorex find?
5Studies of benfluorex measured 5 outcomes, among them cortisol, DHEA sulfate and insulin response.
Cortisol
no changein humans1
1 study
Cortisol
no changein humans1
Benfluorex showed no clear effect on cortisol in humans (hypertension, insulin resistance).
“In neither middle-aged nor elderly men did serum cortisol change with benfluorex treatment.”
Human trialhypertension, insulin resistance150 mg three times daily6 weeksmalesn = 27
The Journal of clinical endocrinology and metabolism
DHEA sulfate
upin humans1
1 study
DHEA sulfate
upin humans1
Benfluorex increases DHEA sulfate in humans (hypertension, insulin resistance) (middle-aged: from 6.80 +/- 0.75 to 10.52 +/- 1.02 mumol/L (P < 0.015); elderly: from 5.16 +/- 0.67 to 8.36 +/- 1.21 mumol/L (P < 0.015)).
“Concurrent with the reduction in insulinemia, benfluorex treatment was associated with rises in both serum DHEA sulfate and unconjugated DHEA.”
Human trialhypertension, insulin resistance150 mg three times daily6 weeksmalesn = 27
The Journal of clinical endocrinology and metabolism
Insulin response
downin humans1
1 study
Insulin response
downin humans1
Benfluorex decreases insulin response in humans (hypertension, insulin resistance).
“We conclude that benfluorex treatment lowers blood pressure, improves glucose tolerance, reduces the glucose-stimulated insulin response, and increases serum DHEA and DHEA sulfate in both middle-aged and elderly men.”
Human trialhypertension, insulin resistance150 mg three times daily6 weeksmalesn = 27
The Journal of clinical endocrinology and metabolism
Glucose tolerance
upin humans1
1 study
Glucose tolerance
upin humans1
Benfluorex improves glucose tolerance in humans (hypertension, insulin resistance).
“Benfluorex treatment lowered diastolic and systolic blood pressures and improved glucose tolerance in both age groups.”
Human trialhypertension, insulin resistance150 mg three times daily6 weeksmalesn = 27
The Journal of clinical endocrinology and metabolism
Blood pressure
downin humans1
1 study
Blood pressure
downin humans1
Benfluorex decreases blood pressure in humans (hypertension, insulin resistance).
“Benfluorex treatment lowered diastolic and systolic blood pressures and improved glucose tolerance in both age groups.”
Human trialhypertension, insulin resistance150 mg three times daily6 weeksmalesn = 27
The Journal of clinical endocrinology and metabolism