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Avasopasem manganese

Intervention

1 paper studies it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Holden Comprehensive Cancer Center, University of Iowa and 8 more
  • Animals1

Outcomes

2

Oxidative stress and ROS signaling

downin mice1

1 study

  1. Avasopasem manganese decreases oxidative stress and ROS signaling in mice.

    “Treatment with avasopasem manganese (GC4419), a SOD mimetic, decreased platelet mitochondrial pro-oxidants, cellular ROS levels, and inhibited procoagulant platelet formation and arterial thrombosis in aged mice.”

    Animals

    Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging

    Arteriosclerosis, thrombosis, and vascular biologyNov 3, 2022

More on Oxidative stress and ROS signaling

Thrombosis

downin mice1

1 study

  1. Avasopasem manganese decreases thrombosis in mice.

    “Treatment with avasopasem manganese (GC4419), a SOD mimetic, decreased platelet mitochondrial pro-oxidants, cellular ROS levels, and inhibited procoagulant platelet formation and arterial thrombosis in aged mice.”

    Animals

    Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging

    Arteriosclerosis, thrombosis, and vascular biologyNov 3, 2022

More on Thrombosis

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