Atv/r

Intervention

1 paper studies it2 findings

Across all fields, 1 paper: none in people yet, 1 in cells

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 1 more
  • Cells1

Outcomes

2

Physiological function

downin mice1

1 study
  1. Atv/r impairs physiological function in mice.

    “mice receiving sustained ATV/r treatment showed an increase in senescent cells and age-related decline in physiological function.”

    Animalssustained treatment

    Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal

    Aging cell

Cellular senescence

upin mouse cells1

1 study
  1. Atv/r induces cellular senescence in mouse cells.

    “Upon ATV/r, but not DRN/r, treatment, cells arrested growth, displayed multiple features of senescence, and expressed significantly upregulated levels of many SASP factors.”

    Cellsin cell culture

    Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal

    Aging cell

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