ASGR1 inhibitors
ASGR1 inhibitors has been studied in 1 paper since 2023: 1 observational study in people. The newest paper, Jul 3, 2023: “Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study”.
1 paper studies it6 findingsUpdated
See all 1 papers on ASGR1 inhibitors
At a glance
The findings reach people, from one lab or study. 1 lab in 2 countries.
“Genetically mimicked ASGR1 inhibitors were associated with a longer lifespan (3.31 years per standard deviation reduction in LDL-cholesterol, 95% confidence interval 1.01 to 5.62).”
None of its findings points the other way.
- 1 lab in 2 countries
- Humans1
What did studies of ASGR1 inhibitors find?
5Studies of ASGR1 inhibitors measured 5 outcomes, among them C-reactive protein, IGF-1 and gamma-glutamyltransferase.
C-reactive protein
upin humans1
1 study
C-reactive protein
upin humans1
ASGR1 inhibitors are linked with higher C-reactive protein in humans.
“Genetically mimicked ASGR1 inhibitors were positively associated with alkaline phosphatase, gamma glutamyltransferase, erythrocyte traits, insulin-like growth factor 1 (IGF-1) and C-reactive protein (CRP)”
Humans
BMC medicine
IGF-1
upin humans1
1 study
IGF-1
upin humans1
ASGR1 inhibitors are linked with higher IGF-1 in humans.
“Genetically mimicked ASGR1 inhibitors were positively associated with alkaline phosphatase, gamma glutamyltransferase, erythrocyte traits, insulin-like growth factor 1 (IGF-1) and C-reactive protein (CRP)”
Humans
BMC medicine
Gamma-glutamyltransferase
upin humans1
1 study
Gamma-glutamyltransferase
upin humans1
ASGR1 inhibitors are linked with higher gamma-glutamyltransferase in humans.
“Genetically mimicked ASGR1 inhibitors were positively associated with alkaline phosphatase, gamma glutamyltransferase, erythrocyte traits, insulin-like growth factor 1 (IGF-1) and C-reactive protein (CRP)”
Humans
BMC medicine
Apolipoprotein B
downin humans1
1 study
Apolipoprotein B
downin humans1
ASGR1 inhibitors are linked with lower Apolipoprotein B in humans.
“Genetically mimicked ASGR1 inhibitors were inversely associated with apolipoprotein B (apoB), triglycerides (TG) and CAD risk.”
Humans
BMC medicine
Lifespan
upin humans1
1 study
Lifespan
upin humans1
ASGR1 inhibitors are linked with longer lifespan in humans (colocalization probability 0.42) (3.31 years per SD reduction in LDL-cholesterol (95% CI 1.01 to 5.62)).
“Genetically mimicked ASGR1 inhibitors were associated with a longer lifespan (3.31 years per standard deviation reduction in LDL-cholesterol, 95% confidence interval 1.01 to 5.62).”
Humanscolocalization probability 0.42
BMC medicine
What is ASGR1 inhibitors linked with?
1Studies link ASGR1 inhibitors with coronary artery disease.
Coronary artery disease
downin humans1
1 study
Coronary artery disease
downin humans1
ASGR1 inhibitors are linked with a lower risk of coronary artery disease in humans (colocalization probability 0.30).
“Genetically mimicked ASGR1 inhibitors were inversely associated with apolipoprotein B (apoB), triglycerides (TG) and CAD risk.”
Humanscolocalization probability 0.30
BMC medicine