Arachidonyl-2'-chloroethylamide
Also called ACEA
Arachidonyl-2'-chloroethylamide has been studied in 3 papers since 2016: none in people yet, 1 in animals, 2 in cells. The research so far is in animals and cells. The newest paper, Aug 25, 2023: “Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p”.
See all 3 papers on arachidonyl-2'-chloroethylamide
At a glance
The findings reach cells, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 3 more
- Animals1
- Cells2
What did studies of arachidonyl-2'-chloroethylamide find?
4Studies of arachidonyl-2'-chloroethylamide measured 4 outcomes, among them MIR191, SIRT1 and senescence gene expression.
MIR191
downin rat cells1
1 study
MIR191
downin rat cells1
Arachidonyl-2'-chloroethylamide decreases MIR191 in HU-induced senescent cells.
“Increased expression of miR-191-5p by HU was restored by CB1 agonist ACEA co-treatment.”
Cellsin HU-induced senescent cells
Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p
Frontiers in endocrinology
SIRT1
upin human cells1
1 study
SIRT1
upin human cells1
Arachidonyl-2'-chloroethylamide increases SIRT1 in human cells.
“agonist arachidonyl-2-chloroethylamide enhanced the expression of sirt1.”
Cells
Experimental biology and medicine (Maywood, N.J.)
Senescence gene expression
downin human cells1
1 study
Senescence gene expression
downin human cells1
Arachidonyl-2'-chloroethylamide decreases senescence gene expression in interleukin-1β-treated chondrocytes.
“interleukin-1βtreatment significantly increased the expressions of senescence genes (caveolin-1, PAI-1 and p21), which were prevented by agonist arachidonyl-2-chloroethylamide treatment.”
Cellsin interleukin-1β-treated chondrocytes
Experimental biology and medicine (Maywood, N.J.)
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Arachidonyl-2'-chloroethylamide decreases cellular senescence in interleukin-1β-induced senescence.
“Our findings demonstrate that agonist arachidonyl-2-chloroethylamidedecreased senescence-associated β-galactosidase activity and cell cycle arrest in the G0/G1 phase induced by interleukin-1β.”
Cellsin interleukin-1β-induced senescence
Experimental biology and medicine (Maywood, N.J.)