AP39

AP39 improves healthspan in worms.

“Health span, but not life span, increased with all adult-onset mtH2S treatments.”

Model organisms

Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America·Jul 31, 2023

AP39 improves physical function in worms.

“mtH2S preserved aging mitochondrial structure, content (citrate synthase activity) and neuromuscular strength.”

Model organisms100 nM

Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America·Jul 31, 2023

AP39 extends lifespan in worms.

“Developmentally administered mtH2S (100 nM) improved life/health span vs. equivalent untargeted H2S doses.”

Model organisms100 nM

Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America·Jul 31, 2023