Anti-tau single-domain antibodies

1. Anti-tau single-domain antibodies extend lifespan in flies.

   “attenuating or preventing tau-induced phenotypes that typically manifest as defects in neuronal axonal transport, neurodegeneration, functional impairments, and shortened lifespan.”

   Model organismsDrosophila tauopathy modeltransgenic expressionneurons or neuronal subtypes

   Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

   Cell death & disease·30 Jul 2024

1. Anti-tau single-domain antibodies decrease functional impairments in flies.

   “attenuating or preventing tau-induced phenotypes that typically manifest as defects in neuronal axonal transport, neurodegeneration, functional impairments, and shortened lifespan.”

   Model organismsDrosophila tauopathy modeltransgenic expressionneurons or neuronal subtypes

   Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

   Cell death & disease·30 Jul 2024

1. Anti-tau single-domain antibodies decrease neurodegeneration in flies.

   “attenuating or preventing tau-induced phenotypes that typically manifest as defects in neuronal axonal transport, neurodegeneration, functional impairments, and shortened lifespan.”

   Model organismsDrosophila tauopathy modeltransgenic expressionneurons or neuronal subtypes

   Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

   Cell death & disease·30 Jul 2024

1. Anti-tau single-domain antibodies improve neuronal axonal transport in flies.

   “attenuating or preventing tau-induced phenotypes that typically manifest as defects in neuronal axonal transport, neurodegeneration, functional impairments, and shortened lifespan.”

   Model organismsDrosophila tauopathy modeltransgenic expressionneurons or neuronal subtypes

   Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

   Cell death & disease·30 Jul 2024

1. Anti-tau single-domain antibodies decrease pathological tau in flies.

   “Three of these sdAbs showed therapeutic potential in various assays, effectively clearing pathological tau”

   Model organismsDrosophila tauopathy modeltransgenic expressionneurons or neuronal subtypes

   Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

   Cell death & disease·30 Jul 2024

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