ANTI-PD-L2

Intervention

1 paper2 findings

  • 1 lab
  • Animals1

Outcomes

2

Tumour-infiltrating interferon-gamma+ immune cells

upin mice1

1 study
  1. ANTI-PD-L2 increases tumour-infiltrating interferon-gamma+ immune cells in mice.

    “αPD-L2 increases tumour-infiltrating interferon-γ+ immune cell prevalence and interferon-γ production in aged but not young melanoma-bearing hosts in an unexpectedly IL-17-dependent manner.”

    Animalsin melanoma-bearing hosts

    Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

    Nature communications19 Nov 2025

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Melanoma

downin mice1

1 study
  1. ANTI-PD-L2 decreases melanoma in mice.

    “αPD-L2 fails in young B16-bearing mice but is effective in aged.”

    Animalsin B16-bearing mice

    Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

    Nature communications19 Nov 2025

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