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ANTI-PD-1 monoclonal antibody

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: Emberi Eroforrások Minisztériuma and others
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

1

Cardiac systolic function

no changein mice1downin mice1

1 study

  1. ANTI-PD-1 monoclonal antibody has no effect on cardiac systolic function in mice.

    “cardiac systolic functions significantly decreased in CON, but not in HFD + L-NAME groups of both sexes compared to baseline”

    AnimalsHFD + L-NAMEheart2 weeksn = 7

    Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice

    Basic research in cardiologyNov 8, 2024

  2. ANTI-PD-1 monoclonal antibody decreases cardiac systolic function in mice.

    “cardiac systolic functions significantly decreased in CON, but not in HFD + L-NAME groups of both sexes compared to baseline”

    Animalscontrol diet (CON)heart2 weeksn = 7

    Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice

    Basic research in cardiologyNov 8, 2024

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