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ANTI-GDF11 antibody

Intervention

2 papers study it3 findings

Across all fields, 2 papers: none in people yet, 2 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 1 country
  • Funders: National Institutes of Health and 2 more
  • Animals2

Outcomes

3

Peri-implant bone healing

upin mice1

1 study

  1. ANTI-GDF11 antibody improves peri-implant bone healing in mice.

    “inhibition of GDF11 improved peri-implant bone healing in old mice”

    Animalsfemurmales

    Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss

    Journal of periodontology

Liver regeneration

upin mice1

1 study

  1. ANTI-GDF11 antibody improves liver regeneration in mice.

    “In contrast, inhibition of GDF11 activity with neutralizing Abs significantly decreased liver injury and improved liver regeneration after IRI.”

    Animalsafter liver ischemia reperfusion injuryliver

    Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hepatocellular injury

downin mice1

1 study

  1. ANTI-GDF11 antibody decreases hepatocellular injury in mice.

    “In contrast, inhibition of GDF11 activity with neutralizing Abs significantly decreased liver injury and improved liver regeneration after IRI.”

    Animalsafter liver ischemia reperfusion injuryliver

    Growth differentiation factor 11 worsens hepatocellular injury and liver regeneration after liver ischemia reperfusion injury

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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