Growth differentiation factor 11

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: American Heart Association and 6 more
1 of 1 finding with company ties

Animals1

Outcomes

Cognitive function

upin mice1

1 study

Growth differentiation factor 11 improves cognitive function in mice.
“Restoration of youthful levels of GDF11 by injection partially restores brain function and neurogenesis by improving endothelial cell function and vasculature.”
Reviewrestoration of youthful levels by injection
Systemic factors mediate reversible age-associated brain dysfunction
Rejuvenation research1 Dec 2014

neurogenesis

upin mice1

1 study

Growth differentiation factor 11 increases neurogenesis in mice.
“Restoration of youthful levels of GDF11 by injection partially restores brain function and neurogenesis”
Reviewrestoration of youthful levels by injectionbrain
Systemic factors mediate reversible age-associated brain dysfunction
Rejuvenation research1 Dec 2014

Cardiac hypertrophy

downin mice1

1 study

Growth differentiation factor 11 decreases cardiac hypertrophy in mice.
“Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy”
Animals
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Cell9 May 2013