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Anti-apolipoprotein d antibody

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals1

Outcomes

2

Senescent skin phenotype

downin mice1

1 study

  1. Anti-apolipoprotein d antibody decreases senescent skin phenotype in mice.

    “reduced the number of senescent cells in the dermis of mice and improved the senescent skin phenotype.”

    Animalsantibody-drug conjugate treatment combined with administration of antibodiesskin

    New Senolysis Approach via Antibody-Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation

    International journal of molecular sciences20 Mar 2023

Senescent cell count

downin mouse cells1

1 study

  1. Anti-apolipoprotein d antibody decreases senescent cell count in mouse cells.

    “The concurrent administration of the antibody with the PBD-conjugated secondary antibody specifically eliminated only senescent cells without harming young cells.”

    Cellsconcurrent administration of anti-apolipoprotein D antibody and pyrrolobenzodiazepine-conjugated secondary antibody

    New Senolysis Approach via Antibody-Drug Conjugate Targeting of the Senescent Cell Marker Apolipoprotein D for Skin Rejuvenation

    International journal of molecular sciences20 Mar 2023

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