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Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine

Intervention

1 paper5 findings

PubChem 936PubChem 864PubChem 1130PubChem 1052PubChem 638024ChEBI 17154ChEBI 16494ChEBI 18385ChEBI 16410ChEBI 28821

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Larry L. Hillblom Foundation and 1 more
  • Animals1

Outcomes

5

Lifespan

upin mice1

1 study

  1. Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine extends lifespan in mice.

    “improves glucose homeostasis and motor coordination, and increases lifespan”

    Animalslate-life intervention

    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

    Cell reports13 Oct 2025

ghrelin signaling

downin mice1

1 study

  1. Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine inhibits ghrelin signaling in mice.

    “Gly-Low inhibits appetite stimulation through ghrelin and AMP-activated protein kinase (AMPK) signaling pathways in the hypothalamus”

    Animalsin the hypothalamus

    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

    Cell reports13 Oct 2025

Survival

upin mice1

1 study

  1. Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine increases survival in mice.

    “improves insulin sensitivity, and increases survival in leptin receptor-deficient (Leprdb) and wild-type C57B6/J mice”

    Animalssupplementation in the diet

    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

    Cell reports13 Oct 2025

Insulin sensitivity

upin mice1

1 study

  1. Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine improves insulin sensitivity in mice.

    “improves insulin sensitivity, and increases survival in leptin receptor-deficient (Leprdb) and wild-type C57B6/J mice”

    Animalssupplementation in the diet

    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

    Cell reports13 Oct 2025

Body weight

downin mice1

1 study

  1. Nicotinamide + alpha-lipoic acid + thiamine + pyridoxamine + piperine decreases body weight in mice.

    “Gly-Low supplementation in the diet reduces food consumption, decreases body weight while preserving muscle mass”

    Animalssupplementation in the diet

    Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

    Cell reports13 Oct 2025

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