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Alginate-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride microcapsules

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Russian Science Foundation
  • Animals1

Outcomes

2

Fibrotic overgrowth

downin rats1

1 study

  1. Alginate-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride microcapsules decrease fibrotic overgrowth in rats (minimal).

    “Histological analysis demonstrated high biocompatibility of the PMETAC coating, resulting in minimal fibrotic overgrowth around the capsules.”

    Animalsin diabetic rats

    Alginate-Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo

    Biomedicines10 Nov 2024

Insulin secretion

upin rats1

1 study

  1. Alginate-poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride microcapsules improve insulin secretion in rats (up to 90 days vs 7 days).

    “The encapsulated islets maintained insulin secretion for up to 90 days, significantly longer than non-encapsulated ones, which ceased functioning after 7 days.”

    Animalsin diabetic ratsup to 90 days

    Alginate-Poly[2-(methacryloyloxy)ethyl]trimethylammonium Chloride (PMETAC) Immunoisolating Capsules Prolong the Viability of Pancreatic Islets In Vivo

    Biomedicines10 Nov 2024

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