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Aldometanib

Intervention

1 paper6 findings

PubChem 165413044

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and others
  • Animals1

Outcomes

5

Lifespan

upin mice1upin worms1

1 study

  1. Aldometanib extends lifespan in mice.

    “Moreover, aldometanib extends lifespan and healthspan in both Caenorhabditis elegans and mice.”

    Animals

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

  2. Aldometanib extends lifespan in worms.

    “Moreover, aldometanib extends lifespan and healthspan in both Caenorhabditis elegans and mice.”

    Model organisms

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

Nonalcoholic steatohepatitis

downin rodents1

1 study

  1. Aldometanib decreases nonalcoholic steatohepatitis in rodents.

    “Aldometanib also alleviates fatty liver and nonalcoholic steatohepatitis in obese male rodents.”

    Animalsobesitylivermales

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

More on Nonalcoholic steatohepatitis

Fatty liver

downin rodents1

1 study

  1. Aldometanib decreases fatty liver in rodents.

    “Aldometanib also alleviates fatty liver and nonalcoholic steatohepatitis in obese male rodents.”

    Animalsobesitylivermales

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

More on Fatty liver

Glucose

downin mice1

1 study

  1. Aldometanib decreases glucose in mice.

    “In male mice, aldometanib elicits an insulin-independent glucose-lowering effect, without causing hypoglycaemia.”

    Animalsinsulin-independent effectmales

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

More on Glucose

AMPK signalling

upin rodents1

1 study

  1. Aldometanib activates AMPK signalling in rodents.

    “blocking FBP binding to aldolase with the small molecule aldometanib selectively activates the lysosomal pool of AMPK and has beneficial metabolic effects in rodents.”

    Animalslysosomal pool

    The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

    Nature metabolism10 Oct 2022

More on AMPK signalling

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