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AFTIN-4

Intervention

1 paper studies it4 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Javna Agencija za Raziskovalno Dejavnost RS and 1 more
  • Animals1

Outcomes

4

GFAP

upin mice1

1 study

  1. AFTIN-4 increases GFAP in mice.

    “In contrast, aged and aftin-4-treated male mice presented elevated levels of GFAP, indicating astrocyte damage.”

    Animalsbrainmales

    A comparison of cognitive decline in aged mice and mice treated with aftin-4

    Scientific reports

More on GFAP

Amyloid-beta

no changein mice1

1 study

  1. AFTIN-4 has no effect on amyloid-beta in mice.

    “no detectable changes in plasma Aβ levels”

    Animalsplasma30 mg/kg

    A comparison of cognitive decline in aged mice and mice treated with aftin-4

    Scientific reports

More on Amyloid-beta

Malondialdehyde

downin mice1

1 study

  1. AFTIN-4 decreases malondialdehyde in mice.

    “Aftin-4 mice presented lower brain MDA levels and no detectable changes in plasma Aβ levels.”

    Animalsbrain30 mg/kg

    A comparison of cognitive decline in aged mice and mice treated with aftin-4

    Scientific reports

More on Malondialdehyde

Cognitive function

no changein mice1

1 study

  1. AFTIN-4 has no effect on cognitive function in mice.

    “Our results revealed no behavioral changes in the aged or aftin-4-treated mice compared with the control mice.”

    Animalscompared with control mice

    A comparison of cognitive decline in aged mice and mice treated with aftin-4

    Scientific reports

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