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Adenovirus-mediated RPL35 overexpression

InterventionPreclinical

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

1

Cartilage degeneration

downin mice1

1 study

  1. Adenovirus-mediated RPL35 overexpression protects against cartilage degeneration in mice.

    “elevated protein levels of RPL35 protected articular chondrocytes from degeneration.”

    Animalsin mouse compression loading and DMM model

    RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling

    Journal of orthopaedic translationApr 1, 2024

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