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ACSL3 gene therapy

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: American Heart Association and 1 more
  • Animals1

Outcomes

2

BDNF

upin mice1

1 study

  1. ACSL3 gene therapy increases BDNF in mice.

    “Upregulation of ACSL3 via adenovirus in aged 3xTg-AD mice led to increased protein levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor C (VEGF-C)”

    Animalsin aged 3xTg-AD miceadenovirusbrain

    ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's disease

    GeroScienceNov 13, 2024

More on BDNF

Depression and anxiety symptoms

upin mice1

1 study

  1. ACSL3 gene therapy improves depression and anxiety symptoms in mice.

    “Upregulation of ACSL3 via adenovirus in aged 3xTg-AD mice led to increased protein levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor C (VEGF-C) (via brain histology, capillary-based immunoassay), resulting in alleviation of depression and anxiety symptoms.”

    Animalsin aged 3xTg-AD miceadenovirus

    ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's disease

    GeroScienceNov 13, 2024

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