Aav1.nt-3 gene therapy

1. Aav1.nt-3 gene therapy activates mTOR signaling in mice.

   “western blot analyses for mTORC1 activation were in accordance with the histological findings.”

   AnimalsAAV1.tMCK.NT-3distal hindlimb muscles1 x 1011 vg6 months

   AAV1.NT-3 gene therapy prevents age-related sarcopenia

   Aging·Mar 9, 2023

More on mTOR signaling

1. Aav1.nt-3 gene therapy decreases sarcopenia in mice.

   “remodeling and fiber size decrease with aging, which was normalized toward values obtained from 10 months old WT mice with treatment.”

   AnimalsAAV1.tMCK.NT-3muscle1 x 1011 vg6 months

   AAV1.NT-3 gene therapy prevents age-related sarcopenia

   Aging·Mar 9, 2023

More on Sarcopenia

1. Aav1.nt-3 gene therapy improves physical function in mice.

   “AAV1.NT-3 gene therapy in WT-aged C57BL/6 mice resulted in functional and in vivo muscle physiology improvements”

   AnimalsAAV1.tMCK.NT-3muscle1 x 1011 vg6 months

   AAV1.NT-3 gene therapy prevents age-related sarcopenia

   Aging·Mar 9, 2023