AAV-PLA2G4E

AAV-PLA2G4E has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 9, 2026: “Gene delivery improved memory in mice modeling Alzheimer’s”.

Intervention

1 paper studies it3 findingsUpdated

See all 1 papers on AAV-PLA2G4E

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.
  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 2 more
  • Animals1

What did studies of AAV-PLA2G4E find?

3

Studies of AAV-PLA2G4E measured 3 outcomes: glycolysis, tau phosphorylation and cognitive function.

Glycolysis

upin mice1

1 study
  1. AAV-PLA2G4E improves glycolysis in AD models and aged wild-type mice.

    “PLA2G4E expression rescued memory deficits, reduced tau phosphorylation, and improved brain glucose metabolism and cognitive performance in AD models and aged wild-type mice.”

    Animalsin AD models and aged wild-type micebrain

    Gene delivery improved memory in mice modeling Alzheimer’s

    Alzheimer's & dementia (New York, N. Y.)

More on Glycolysis

Tau phosphorylation

downin mice1

1 study
  1. AAV-PLA2G4E decreases tau phosphorylation in AD models and aged wild-type mice.

    “PLA2G4E expression rescued memory deficits, reduced tau phosphorylation, and improved brain glucose metabolism and cognitive performance in AD models and aged wild-type mice.”

    Animalsin AD models and aged wild-type micebrain

    Gene delivery improved memory in mice modeling Alzheimer’s

    Alzheimer's & dementia (New York, N. Y.)

More on Tau phosphorylation

Cognitive function

upin mice1

1 study
  1. AAV-PLA2G4E improves cognitive function in AD models and aged wild-type mice.

    “PLA2G4E expression rescued memory deficits, reduced tau phosphorylation, and improved brain glucose metabolism and cognitive performance in AD models and aged wild-type mice.”

    Animalsin AD models and aged wild-type micebrain

    Gene delivery improved memory in mice modeling Alzheimer’s

    Alzheimer's & dementia (New York, N. Y.)

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
Alzheimer's & Dementia

Gene delivery improved memory in mice modeling Alzheimer’s

Gene delivery in an Alzheimer’s mouse model improved memory at two and six months, while partly normalizing disease-related changes in brain fats.Gene delivery in an Alzheimer’s mouse model improved memory at two and six months, while partly normalizing disease-related changes in brain fats.