Aav-mediated oskm expression

Intervention1 paper3 findings

  • Animals1

Outcomes

3

Survival

downin rats1Very low certainty

1 study

  1. Aav-mediated oskm expression decreases survival in rats.

    AnimalsMASH without cirrhosis; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVsingle AAV dosemales

    Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026

Liver tumors

upin rats1Very low certainty

1 study

  1. Aav-mediated oskm expression induces liver tumors in rats.

    AnimalsMASH without cirrhosis; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVliversingle AAV dosemales

    Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026

Liver tumors →

Liver damage

downin rats1Very low certainty

1 study

  1. Aav-mediated oskm expression decreases liver damage in rats.

    Animalswarm hepatic ischemia; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVliversingle AAV dosemales

    Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026

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Communications BiologyAnimals

Three-protein combination eased chronic liver disease in rats

In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.

Interventions

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