Aav-mediated osk expression
Intervention1 paper3 findings
- Animals1
Outcomes
3Survival
upin rats1Very low certainty
1 study
Survival
upin rats1Very low certainty
Aav-mediated osk expression increases survival in rats.
AnimalsMASH and MASH with cirrhosis; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVsingle AAV dosemales
Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026
Liver tissue injury and fibrosis
downin rats1Very low certainty
1 study
Liver tissue injury and fibrosis
downin rats1Very low certainty
Aav-mediated osk expression decreases liver tissue injury and fibrosis in rats.
AnimalsMASH and MASH with cirrhosis; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVliversingle AAV dosemales
Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026
Liver damage
downin rats1Very low certainty
1 study
Liver damage
downin rats1Very low certainty
Aav-mediated osk expression decreases liver damage in rats.
Animalswarm hepatic ischemia; transgene expression activated by doxycycline once a weekdoxycycline-inducible AAVliversingle AAV dosemales
Three-protein combination eased chronic liver disease in rats · Communications biology · 5 Oct 2026
Latest
1Three-protein combination eased chronic liver disease in rats
In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased…In experiments in male Wistar rats, intermittently producing three gene-regulating proteins reduced chronic liver injury and scarring and increased survival.