A2E
- Humans1
Outcomes
3Lipofuscin
no changein humans1
1 study
Lipofuscin
no changein humans1
A2E has no effect on lipofuscin in humans.
“there was no correlation between the distribution of A2E and lipofuscin”
Reviewwith agingretinal pigment epithelium
Progress in molecular biology and translational science14 Jul 2015
Membrane integrity
downin reviews1
1 study
Membrane integrity
downin reviews1
A2E impairs membrane integrity.
“the disruption of membrane integrity through its natural role as an amphiphilic detergent”
Reviewretinal pigment epithelium
A2E: a component of ocular lipofuscin
Photochemistry and photobiology1 Feb 2004
Oxidative stress and ROS signalling
upin reviews1
1 study
Oxidative stress and ROS signalling
upin reviews1
A2E induces oxidative stress and ROS signalling.
“These modes include photoinduced production of ROI, which places additional oxidative stress on RPE cells”
Reviewupon exposure to lightretinal pigment epithelium
A2E: a component of ocular lipofuscin
Photochemistry and photobiology1 Feb 2004
Associations
1Lipofuscin
upin mice1
1 study
Lipofuscin
upin mice1
A2E is associated with lipofuscin in mice.
“in all the mouse models, A2E distribution and lipofuscin fluorescence correlate well”
Reviewretinal pigment epithelium
Progress in molecular biology and translational science14 Jul 2015