2,3,7,8-tetrachlorodibenzo-p-dioxin

1. 2,3,7,8-tetrachlorodibenzo-p-dioxin decreases GAS5 in mice.

   Animalsblood and dried blood spots

   Dried Blood Spot-Based Quantification Indicates Correlation Between lncRNA GAS5, Diabetes, Age, and War Eras in US Veterans · Biology · 2 Sep 2026

GAS5 →

1. 2,3,7,8-tetrachlorodibenzo-p-dioxin increases somatic mutations in humans.

   Reviewvia sustained mitochondrial dysfunction and AMP elevation

   Selective Inhibition of DNA Polymerase Proofreading: A Metabolic-Fidelity Mechanism Explains Agent Orange-Associated Myelodysplasia · Cancers · 23 Aug 2026

1. 2,3,7,8-tetrachlorodibenzo-p-dioxin increases AMP in humans.

   Reviewin adipose tissue / slow release over decades

   Selective Inhibition of DNA Polymerase Proofreading: A Metabolic-Fidelity Mechanism Explains Agent Orange-Associated Myelodysplasia · Cancers · 23 Aug 2026

AMP →