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1918 influenza virus-like particles

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Allergy and Infectious Diseases and 3 more
  • Animals1

Outcomes

2

Alveolar infection

downin mice1

1 study

  1. 1918 influenza virus-like particles protect against alveolar infection in mice.

    “Histopathological assessment showed that aged vaccinated mice had significant protection from alveolar infection”

    Animalslung

    Elicitation of anti-1918 influenza virus immunity early in life prevents morbidity and lower levels of lung infection by 2009 pandemic H1N1 influenza virus in aged mice

    Journal of virologyNov 30, 2011

2009 pandemic H1N1 influenza virus infection

downin mice1

1 study

  1. 1918 influenza virus-like particles protect against 2009 pandemic H1N1 influenza virus infection in mice (fully protected).

    “Furthermore, the 1918 VLPs fully protected aged mice from 2009 pandemic H1N1 virus challenge 16 months after vaccination.”

    Animals16 months after vaccination

    Elicitation of anti-1918 influenza virus immunity early in life prevents morbidity and lower levels of lung infection by 2009 pandemic H1N1 influenza virus in aged mice

    Journal of virologyNov 30, 2011

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