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1-[4-(trifluoromethyl)-3-pyridinyl]-ethanone

Intervention

1 paper3 findings

PubChem 46835485

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Model organisms1

Outcomes

2

Longevity

downin flies1downin M. persicae1

1 study

  1. 1-[4-(trifluoromethyl)-3-pyridinyl]-ethanone shortens lifespan longevity in M. persicae.

    “4-TFPE reduced pupal weight, development, and longevity in both species”

    Model organisms

    Inhibition of Nicotinamidase Impacts Growth, Development, and Lifespan of Drosophila melanogaster and Myzus persicae

    Journal of agricultural and food chemistry3 Sep 2025

  2. 1-[4-(trifluoromethyl)-3-pyridinyl]-ethanone shortens lifespan longevity in flies.

    “4-TFPE reduced pupal weight, development, and longevity in both species”

    Model organisms

    Inhibition of Nicotinamidase Impacts Growth, Development, and Lifespan of Drosophila melanogaster and Myzus persicae

    Journal of agricultural and food chemistry3 Sep 2025

Pupal weight

downin flies1

1 study

  1. 1-[4-(trifluoromethyl)-3-pyridinyl]-ethanone decreases pupal weight in flies.

    “While 4-TFPE reduced pupal weight, development, and longevity in both species”

    Model organisms

    Inhibition of Nicotinamidase Impacts Growth, Development, and Lifespan of Drosophila melanogaster and Myzus persicae

    Journal of agricultural and food chemistry3 Sep 2025

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