1,2,3,4,6-penta-o-galloyl-beta-d-glucose

1. 1,2,3,4,6-penta-o-galloyl-beta-d-glucose decreases TTR amyloid fibrils in human cells.

   “PGG disrupted TTR amyloid fibrils isolated from patient cardiac tissue.”

   Cellsin patient cardiac tissue

   Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids

   iScience·21 Nov 2025

More on TTR amyloid fibrils

1. 1,2,3,4,6-penta-o-galloyl-beta-d-glucose improves healthspan in worms.

   “In Caenorhabditis elegans-expressing human TTR81−127, PGG reduced TTR aggregation and extended both lifespan and healthspan.”

   Model organismsin C. elegans expressing human TTR81-127

   Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids

   iScience·21 Nov 2025

1. 1,2,3,4,6-penta-o-galloyl-beta-d-glucose extends lifespan in worms.

   “In Caenorhabditis elegans-expressing human TTR81−127, PGG reduced TTR aggregation and extended both lifespan and healthspan.”

   Model organismsin C. elegans expressing human TTR81-127

   Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids

   iScience·21 Nov 2025

1. 1,2,3,4,6-penta-o-galloyl-beta-d-glucose decreases TTR aggregation in worms.

   “In Caenorhabditis elegans-expressing human TTR81−127, PGG reduced TTR aggregation and extended both lifespan and healthspan.”

   Model organismsin C. elegans expressing human TTR81-127

   Glycosidic scaffold bearing multiple galloyl moieties from pomegranate disrupts transthyretin amyloids

   iScience·21 Nov 2025

More on TTR aggregation