Advanced Science
Bone-lining organoids support blood stem cells in the lab
The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity.The structures grew through more than 20 transfers to fresh cultures while preserving their mix of cell types and DNA integrity.
Animal cell studyBones and joints
Who was studiedMouse blood stem cells with rat periosteal organoids, 28 days
What changedMore blood stem cells stayed in a resting phase with organoids: approximately 20.1% versus approximately 6.12% in standard medium
The catchResting-state preservation was a proxy; cultured cells failed to restore blood cell production after transplantation