vgll3

1. vgll3 shortens lifespan in killifish.

   “Older mutant males develop melanoma-like tumors, validated via transplantation into immunodeficient rag2 models, and exhibit a shortened lifespan.”

   Animalsvgll3 mutantmales

   An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan

   Nature communications·2 Jun 2026

1. vgll3 increases maturation in killifish.

   “Selective disruption of vgll3 isoforms accelerates male growth and maturation in a dose-dependent manner.”

   Animalsvgll3 disruptionmales

   An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan

   Nature communications·2 Jun 2026

1. vgll3 increases growth in killifish.

   “Selective disruption of vgll3 isoforms accelerates male growth and maturation in a dose-dependent manner.”

   Animalsvgll3 disruptionmales

   An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan

   Nature communications·2 Jun 2026

1. vgll3 raises the risk of melanoma-like tumors in killifish.

   “Older mutant males develop melanoma-like tumors, validated via transplantation into immunodeficient rag2 models, and exhibit a shortened lifespan.”

   Animalsvgll3 mutantmales

   An antagonistically pleiotropic gene regulates vertebrate growth, maturity, and lifespan

   Nature communications·2 Jun 2026

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